February 2018

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NSF Toxicologists Win Society of Toxicology’s Best Paper of the Year Award

A paper coauthored by two NSF toxicologists has won the Best Paper of the Year Award by the Regulatory and Safety Evaluation Specialty Section (RSESS) of the Society of Toxicology. The authors — Brad Lampe, Senior Research Toxicologist at NSF; Emily Fuller, a former NSF toxicology intern; and SP Kuppusamy of the National Institute for Occupational Safety and Health — will receive the award on March 12, 2018 at the RSESS reception during the Society of Toxicology annual meeting in San Antonio, Texas.

The article, “A quantitative comparison of points of departure between 28-day and 90-day repeated dose studies with a proposed extrapolation factor,” was published in the February 2018 edition of the Journal of Regulatory Toxicology and Pharmacology.

The article addresses the influence of exposure duration on chemical toxicity, which is a common source of uncertainty in risk assessment. It describes research efforts by NSF toxicologists to quantify the effects of exposure duration on chemical toxicity using novel datasets and methods, and proposes a 10-fold uncertainty factor to be applied to datasets that include a 28-day study but lack a subchronic 90-day study.

The results presented in the article demonstrate that some limited datasets that lack a subchronic 90-day study can still be utilized, via the application of the proposed uncertainty factor, to support threshold exposure levels for certain chemicals without the need for additional animal testing. It is also anticipated that these results will facilitate further discussions on the future state of testing requirements in the international regulatory community.