Skip to main content

NSF Launches Protocol 549 for Glyphosate Reduction Claims

P549 is the first standard globally that validates glyphosate reduction performance of water filtration systems and products.

Reverse osmosis water purification system under sink in a kitchen.  Water cleaning system installation. 3d illustration

ANN ARBOR, Mich. — NSF, a global public health organization, today launched NSF Protocol 549 (P549), which provides independent verification that products reduce glyphosate as claimed.

Glyphosate is the most widely used herbicide globally. As consumer interest in verified contaminant reduction claims continues to grow, NSF has sought to develop standards, certifications and protocols that address their demands and prioritize their health and wellbeing.

Prior to today’s debut of P549, no authoritative, standardized certification provided a credible, science-based way to validate the performance of water filtration systems and products as they relate to glyphosate reductions. NSF helps bridge that gap through independent verification backed by rigorous science and globally recognized certification expertise.

“NSF Protocol 549 is the first globally designed to measure a reduction of glyphosate through trusted, science-based third-party testing,” said Vincent Boks, VP of Water, NSF. “NSF Protocol 549 enables manufacturers to differentiate their products by being among the first to independently verify glyphosate reduction performance.”

Herbicides are the most used agricultural chemical in history, and glyphosate is a broad-spectrum systemic herbicide and crop desiccant used for weed control in agricultural settings. It enters the water supply through two primary mechanisms: agricultural runoff, and its byproduct aminomethylphosphonic acid (AMPA) that persists in the environment.

According to the World Health Organization (WHO), glyphosate is “probably carcinogenic to humans,” and the Centers for Disease Control and Prevention (CDC) found that glyphosate exposure can result in negative respiratory effects in humans, and negative development effects in animals.

P549 is aligned with existing standardized, science-based testing protocols, including NSF/ANSI 53, which establishes minimum requirements for systems designed to reduce specific health-related contaminants, and NSF/ANSI 58, which includes requirements addressing various aspects of point-of-use (POU) reverse osmosis (RO) systems.

“Aligning with existing NSF certifications, NSF Protocol 549 further prioritizes public health by providing consumers with peace of mind that their water filtration systems and products reduce their potential exposure to glyphosate,” said Jérôme Logie, Senior Director of Water, NSF. “This protocol continues to position NSF as a trusted global public health authority for consumers, and provides manufacturers a standard of safety for their filtration systems and products.”

To comply with P549, tested filtration systems and products are required to reduce the amount of glyphosate in the resulting water to 0.28mg/L or lower, a recognized health-protective benchmark. Glyophaste reduction can be achieved through filtration systems and products utilizing methodology including adsorption through activated carbon and reverse osmosis.

How NSF Can Help You

Get in touch to find out how we can help you and your business thrive.

What’s New with NSF

  • Cambium Analytica, an NSF Company, Opens New Lab in Traverse City, Mich

    October 6, 2026
    Ribbon cutting debuts innovative 15,000-square-foot testing facility to support evolving needs of the food & supplement industries.
    Read the Story
  • Young beautiful athlete woman training on outdoors exercise bike in park and eating energy bar.

    NSF Drives Industry Conversations at SupplySide Global 2026 - Las Vegas, Oct. 26–30

    September 17, 2026
    NSF returns to SupplySide Global with expert-led training and trusted certification solutions. Visit Booth 4741 to discover how NSF and Cambium Analytica help brands build trust, increase consumer confidence and stand out in a competitive marketplace.
    Read the Story
  • NSF Welcomes Hanjun Kwon, Managing Director, APAC

    September 14, 2026
    Experienced business leader to drive sustainable growth, organizational development and operational excellence across the Asia-Pacific region.
    Read the Story
  • A mother and her son standing in the kitchen as she prepares food for lunch. He is eating a strawberry while he watches. Mom is Caucasian, in her 30s and the boy is mixed race Black and Caucasian, 3 years old. The focus is on the woman.

    NSF to Exhibit and Present at PACK EXPO International

    September 11, 2026
    NSF is proud to be part of PACK EXPO International 2026, the premier event bringing together packaging and processing leaders from across industries.
    Read the Story