NSF/ANSI 455 Standard Transition for Supplements, Cosmetics and OTCs

NSF International has worked with industry representatives, public health officials, regulators and consumer interest groups to develop the NSF/ANSI 455 GMP audit standards over the past five years.

NSF International is transitioning clients from its current GMP registration (NSF/ANSI 173 Section 8) to NSF/ANSI 455 GMP certification to be able to certify facilities to a consensus-based national standard, and to allow manufacturers to reduce their annual audit burden.

We are currently accepting applications for audits for dietary supplements (455-2), cosmetics/personal care products (455-3) and OTC drugs (455-4). The current dietary supplement GMP registration will be phased out entirely by 2022, while the GMP registration for cosmetics will be phased out by 2021.

The updates to the NSF/ANSI 173 GMP registration for dietary supplements audits implemented in 2019 were the first step toward this new standard, and incorporated many of the audit requirements of NSF/ANSI 455-2. For manufacturers, the key differences between GMP registration and the NSF/ANSI 455 GMP certification are:

  • The leading GMP audits for dietary supplements, cosmetics and OTC drugs based on current Good Manufacturing Practices and current federal regulations for each scope
  • A defined audit process that determines audit duration, timeline for CAR reviews and ongoing monitoring requirements
  • A grading system based on the number and severity of non-conformances
  • Best industry practices based on retailer requirements
  • Certification audits accredited by ANSI starting in 2020
  • Certification recognized by the Global Retailer and Manufacturer Alliance (GRMA) made up of leading retailers, manufacturers and other stakeholders
On-Demand Webinar
Introduction to the standards to make the move more straightforward while providing background information. This session is no cost to you.

NSF/ANSI 455-2 Dietary Supplements

GMP Certified NSF/ANSI 455-2 Dietary Supplements

Transition smoothly from NSF/ANSI 173 GMP registration to NSF/ANSI 455-2.

To help you understand this new international standard for Good Manufacturing Practices (GMPs), NSF has developed resources to simplify your migration process.

If you are a current NSF client, please check the Announcements section of your NSF Connect portal for additional tools.

FAQ: Our team of experts have answered a list of frequently asked questions (FAQs) for your convenience.

NSF/ANSI 455 Process Overview: Offers a clear overview of the process in becoming NSF/ANSI 455-2 certified.

Transition Guide: Contains a full overview of NSF/ANSI 455-2 GMP certification, a comparison chart of the new standard vs. GMP registration, a transition timeline and a detailed comparison table of audit templates.

Information Guide: Contains facts about NSF/ANSI 455-2, key changes from NSF/ANSI173 GMP registration and information about how to prepare for the new standard.

GMP Summit Videos: Review the breakdown of the upgraded standard as the technical team goes through each of the sections of the standard. Make the move to NSF/ANSI 455-2 more straightforward while gaining background information about the standard. The sessions are no cost to you.

On-Demand Webinar
Make the move to NSF/ANSI 455-2 more straightforward and learn background information about the standard. This session is no cost to you.

NSF/ANSI 455-3 Cosmetic and Personal Care Products

GMP Certified NSF/ANSI 455-3 Cosmetic

To help you understand this new international Good Manufacturing Practice (GMP) standard, NSF has developed resources to simplify your certification process.

If you are a current NSF client, please check the Announcements section of your NSF Connect portal for additional tools.

NSF/ANSI 455 Process Overview: Offers a clear overview of the process in becoming 455-3 certified.

Information Guide: Contains facts about 455-3, key items from the new standard and information on preparing for upcoming audits.

GMP Summit Videos: Review the breakdown of the upgraded standard as the technical team goes through each of the sections of the standard. Make the move to NSF/ANSI 455-3 more straightforward while gaining background information about the standard. The sessions are no cost to you.

On-Demand Webinar
Make the move to NSF/ANSI 455-3 more straightforward and learn background information about the standard. This session is no cost to you.

NSF/ANSI 455-4 Over-the-Counter Drugs (OTCs)

GMP Certified NSF/ANSI 455-4 OTC Drugs

To help you understand this new international Good Manufacturing Practice (GMP) standard, NSF has developed resources to simplify your certification process.

If you are a current NSF client, please check the Announcements section of your NSF Connect portal for additional tools.

NSF/ANSI 455 Process Overview: Offers a clear overview of the process in becoming 455-4 certified.

Information Guide: CContains facts about 455-4, key items from the new standard and information on preparing for upcoming audits.

GMP Summit Videos: Review the breakdown of the upgraded standard as the technical team goes through each of the sections of the standard. Make the move to NSF/ANSI 455 more straightforward while gaining background information about the standard. The sessions are no cost to you.

On-Demand Webinar
Make the move to NSF/ANSI 455-4 more straightforward and learn background information about the standard. This session is no cost to you.

Other Resources in Development

Please check back periodically for additional tools to help you throughout the migration process.